Seasonal Comparison
Core FeatureExplore molecular changes across different physiological stages of the hibernation cycle
Hibernation Cycle Timeline
Active vs Torpor
Core Temp
-89%
37°C
4°C
Heart Rate
-99%
350 bpm
5 bpm
Metabolic Rate
-97%
100%
3%
Oxygen Consumption
-98%
100%
2%
UCP1 Expression
-90%
1.0
0.1
Fatty Acid Oxidation
+250%
1.0
3.5
Body Temperature Curve
FallWinterSpring
Active (37°C)
Torpor (4°C)
Multi-Omics Change Overview
| Omics Type | Active State | Torpor State | Key Changes |
|---|---|---|---|
| Transcriptomics | Normal mRNA turnover | mRNA accumulation and stabilization | Translation suppression causes mRNA buildup; cold-inducible RBM3 highly expressed |
| Proteomics | Normal protein synthesis | Global translational inhibition | HSP70, HSP90 chaperones upregulated; mitochondrial proteins selectively degraded |
| Metabolomics | Glycolysis dominant | Fatty acid oxidation dominant | BHB and carnitine derivatives elevated; amino acid metabolism reprogrammed |
| Epigenomics | Normal methylation | Global hypomethylation | DNA methylation reduced; histone acetylation changes regulate metabolic genes |